Clinical Research
A randomized, double-blind, placebo-controlled study involving 67 overweight adults ages 25-60 was conducted over eight weeks to evaluate the efficacy of 300 mgs of CQR-300 daily in reducing the percentage of body fat. Multiple baseline and post-study weight and fat measurements were taken, including body imaging with dual-energy X-ray absorption (DEXA), the gold standard for assessing body fat percentages.
After eight weeks, the CQR-300 group:
Lost an average of 16.3 pounds, compared with 1.3 pounds for the placebo group.
Reduced body fat 12.8% as measured by DEXA, compared with 0.3% gain in body fat in the placebo group.
Trimmed waist circumference 8.9%, compared with a 1.6% reduction in the control group.
Reduced hip circumference 7.7%, compared with a 1.8% decrease in the placebo group.
Experienced statistically significant improvements in blood pressure, total cholesterol, triglycerides and leptin and adiponectin, two hormones that help regulate satiety, appetite and metabolism.
Clinical studies
The Use of a Stem and Leaf Aqueous Extract of Cissus quadrangularis (CQR-300) to Reduce Body Fat and Other Components of Metabolic Syndrome in Overweight Participants. The Journal of Alternative and Complementary Medicine. 2019.
The Use of Cissus quadrangularis (CQR-300) in the Management of Components of Metabolic Syndrome in Overweight and Obese Participants. Natural Product Communications. 2015.
The Use of a Cissus quadrangularis/Irvingia gabonensis Combination in the Management of Weight Loss: a Double-blind, Placebo-controlled Study. Lipids in Health and Disease. 2008.
The Use of a Stem and Leaf Aqueous Extract of Cissus quadrangularis (CQR-300) to Reduce Body Fat and Other Components of Metabolic Syndrome in Overweight Participants. The Journal of Alternative and Complementary Medicine. 2019.
The Use of Cissus quadrangularis (CQR-300) in the Management of Components of Metabolic Syndrome in Overweight and Obese Participants. Natural Product Communications. 2015.
The Use of a Cissus quadrangularis/Irvingia gabonensis Combination in the Management of Weight Loss: a Double-blind, Placebo-controlled Study. Lipids in Health and Disease. 2008.
Preclinical Research / Safety-Tox Studies
Safety Assessment of Cissus quadrangularis Extract (CQR-300): Subchronic Toxicity and Mutagenicity Studies. Food and Chemical Toxicology. 2011.
Inhibitory Effects of Cissus quadrangularis L. Derived Components on Lipase, Amylase and α-Glucosidase Activity in vitro. Natural Products Communication. 2007.
